glp 1 interactions with other drugs This recent podcast episode discusses the side effects of GLP-1 agonists and the potential for drug-drug interactions, as well as how to best to manage these issues when they arise. Listen and GLP-1 vs. Other Medications: Interaction

Occasional headache or lightheadedness during initial dosing

Di Marco et al., 2022)

A novel N-terminal domain may dictate the glucose response of Mondo proteins

Basic Concentration Formula Volume (mL) = Mass of peptide (mg) / Target concentration (mg/mL) Example: - Vial contents: 5 mg AOD-9604 - Target stock concentration: 1 mg/mL - Required volume: 5 mg / 1 mg/mL = 5.0 mL Adjusting for Net Peptide Content If your COA reports a net peptide content below 100% (common when water and counterion weight is factored in), adjust for actual peptide mass: Actual peptide mass (mg) = Stated vial weight (mg) (Net peptide content % / 100) Example: - Vial: 5 mg stated weight - Net peptide content per COA: 85% - Actual peptide mass: 5 0.85 = 4.25 mg - Adjusted reconstitution volume for 1 mg/mL: 4.25 mL For precise in vitro dosing experiments, this correction step is important for reproducibility

This is mildly unsettling, since I recently binge-watched the HBO sci-fi series Westworld, in which Harris plays a menacing gunslinger, but Reed is the opposite of scary, and soon were joking about achy bodies and foggy minds

Doi:10.1056/NEJMoa2404881 Pi-Sunyer X, Astrup A, Fujioka K, et al